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A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis - ScienceDirect
![The D816V mutation in the catalytic domain of the c-Kit receptor downstream tyrosine kinase in peripheral blood mononuclear cells (by M. Niedoszytko). The D816V mutation in the catalytic domain of the c-Kit receptor downstream tyrosine kinase in peripheral blood mononuclear cells (by M. Niedoszytko).](https://s3-eu-west-1.amazonaws.com/ppreviews-plos-725668748/2631302/preview.jpg)
The D816V mutation in the catalytic domain of the c-Kit receptor downstream tyrosine kinase in peripheral blood mononuclear cells (by M. Niedoszytko).
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Novelty Nobility Challenges “Development of an AMD Therapeutic Agent with a New Mechanism, c-KIT” - 바이오스펙테이터
![Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition | PNAS Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition | PNAS](https://www.pnas.org/cms/10.1073/pnas.1610179113/asset/eabf3edf-0c91-4675-90d6-a8f8f4bf0f0b/assets/graphic/pnas.1610179113fig01.jpeg)
Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition | PNAS
![Schematic diagram of c-kit tyrosine kinase receptor. The most common... | Download Scientific Diagram Schematic diagram of c-kit tyrosine kinase receptor. The most common... | Download Scientific Diagram](https://www.researchgate.net/publication/266091193/figure/fig3/AS:644264639856640@1530616068365/Schematic-diagram-of-c-kit-tyrosine-kinase-receptor-The-most-common-mutations.png)
Schematic diagram of c-kit tyrosine kinase receptor. The most common... | Download Scientific Diagram
![Cancers | Free Full-Text | KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer Cancers | Free Full-Text | KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer](https://www.mdpi.com/cancers/cancers-14-02781/article_deploy/html/images/cancers-14-02781-g006.png)
Cancers | Free Full-Text | KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer
![KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis | Leukemia KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis | Leukemia](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fleu.2015.24/MediaObjects/41375_2015_Article_BFleu201524_Fig1_HTML.jpg)
KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis | Leukemia
![The KIT receptor tyrosine kinase. (A) C-KIT mutations occur in 80 –90%... | Download Scientific Diagram The KIT receptor tyrosine kinase. (A) C-KIT mutations occur in 80 –90%... | Download Scientific Diagram](https://www.researchgate.net/publication/51031327/figure/fig3/AS:305865690238985@1449935471527/The-KIT-receptor-tyrosine-kinase-A-C-KIT-mutations-occur-in-80-90-of-GISTs.png)
The KIT receptor tyrosine kinase. (A) C-KIT mutations occur in 80 –90%... | Download Scientific Diagram
![Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy - ScienceDirect Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0145212601000285-gr1.gif)
Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy - ScienceDirect
![Frontiers | Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models Frontiers | Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models](https://www.frontiersin.org/files/Articles/498757/fgene-11-00138-HTML-r1/image_m/fgene-11-00138-g001.jpg)
Frontiers | Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models
Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity | PLOS Computational Biology
![A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth | Journal of Cancer Research and Clinical Oncology A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth | Journal of Cancer Research and Clinical Oncology](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs00432-020-03490-6/MediaObjects/432_2020_3490_Fig4_HTML.png)
A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth | Journal of Cancer Research and Clinical Oncology
![Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis | Scientific Reports Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fsrep13718/MediaObjects/41598_2015_Article_BFsrep13718_Fig1_HTML.jpg)
Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis | Scientific Reports
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